Acta Pharm. 70 (2020) 1-15


full paper



Poly(3-hydroxybutyrate): Promising biomaterial for bone tissue engineering


1 University of Maribor, Faculty of Medicine, Institute of Biomedical Sciences, Maribor, Slovenia

2 University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory for Separation Processes, Maribor, Slovenia

Accepted June 24, 2019

Published online July 31, 2019


Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1af, primaquine bis-ureas 2af, chloroquine fumardiamides 3af and mefloquine fumardiamides 4af. Their antiproliferative activities against breast adenocarcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.


Keywords: poly(3-hydroxybutyrate), biopolymers, bone tissue engineering, osteoblasts