Acta Pharm. 68 (2018) 223-233

 

full paper

Short communication

 

Topical antifungal bigels: Formulation, characterization and evaluation

AGNE MAZURKEVICIUTE, KRISTINA RAMANAUSKIENE, MARIJA IVASKIENE, AIDAS GRIGONIS and VITALIS BRIEDIS

agne.mazurkeviciute@lsmuni.lt

1 Department of Clinical Pharmacy, Faculty of Pharmacy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania

2 Department of Non-infectious Diseases, Faculty of Veterinary Medicine, Veterinary Academy, Lithuanian University of Health Science, 47181 Kaunas, Lithuania

Accepted December 21, 2017

Published online February 6, 2018

 

Bigels with antifungal substances, ciclopirox olamine and terbinafine hydrochloride, were made of hydrogel (poloxamer 407 gel) and oleogel (polyethylene and liquid paraffin mixture). Prepared bigels were found physically stable at room temperature for six months and at least four months at 40 C. Released amount of drug decreased when oleogel concentration in the formulation increased. Release test results depended on the insertion place of active substances. The amount of released substance was highest when ciclopirox olamine was incorporated in both phases in an equal quantity, and terbinafine hydrochloride in oleogel or in hydrogel. All formulations showed great inhibition of Microsporum canis. Thus, bigels with ciclopirox olamine and terbinafine hydrochloride are a promising dosage form for topical use.

 

Keywords: bigel, ciclopirox olamine, terbinafine hydrochloride, poloxamer 407, antifungal, Microsporum canis