Acta Pharm. 68 (2018) 235-242

 

full paper

Short communication

In vitro oxidative stress regulatory potential of Citrullus colocynthis and Tephrosia apollinea

TANIA SHAMIM RIZVI, ABDUL LATIF KHAN, LIAQAT ALI, NARJIS AL-MAWALI, FAZAL MABOOD, JAVID HUSSAIN, MUHAMMAD ADNAN and AHMED AL-HARRASI

taniarizvi722003@gmail.com; aharrasi@unizwa.edu.om

1 UoN Chair of Omanís Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman

2 Department of Chemistry, University of Sargodha, Pakistan

3 Department of Biological Science and Chemistry, University of Nizwa, Birkat Al-Mouz, Nizwa-616, Oman

4 Department of Botany, Kohat University of Science and Technology, Kohat-26000, Pakistan

Accepted December 4, 2017

Published online January 26, 2018

 

The present study investigates the potential role of medicinal plants Citrullus colocynthis and Tephrosia apollinea in ameliorating the oxidative stress developed during the generation of reactive oxygen species. Organic extracts of different organs (leaf, stem and root) of these medicinal plants obtained in n-hexane, chloroform, n-butanol and water were assayed for radical scavenging, total antioxidant capacity, anti-lipid peroxidation and reduced glutathione. The total phenolic content (TPC) of both selected medicinal plants was also evaluated. The results indicated that extracts of T. apollinea leaf, stem and root have higher TPC compared to those of C. colocynthis. Similarly, the results of the present study revealed higher bioactivity of C. colocynthis than that of T. apollinea in various antioxidant assays. Various plant parts of each plant were also compared.

 

Keywords: Citrullus colocynthis, Tephrosia apollinea, oxidative stress, total phenolics