Acta Pharm. 53 (2003) 305-311

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Interaction between chloroquine sulphate and aqueous extract of Azadirachta indica A. Juss (Meliaceae) in rabbits

SUNDAY VITALIS NWAFOR,* PETER ACHUNIKE AKAH, CHARLES OGBONNAYA OKOLI,
ADAOMA CHINAEMEREM ONYIRIOHA and CHUKWUEMEKA SYLVESTA NWORU


svnwafor@hotmail.com

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
Received October 10, 2002      Accepted October 6, 2003

This study was carried out to investigate the effect of concurrent oral administration of aqueous leaf extract of Azadirachta indica (Meliaceae) on the pharmacokinetic properties of chloroquine sulphate in experimental rabbits. The results indicated that concurrent administration of both agents resulted in a significant decrease in serum concentration, slower absorption and elimination as well as longer half life of chloroquine sulphate. The highest relative decrease of 78.0% was recorded 4 hours after concurrent administration, while the smallest decrease (64.6%) occurred 24 hour after concurrent administration. Significant reductions were also noted in some pharmacokinetic parameters of chloroquine and included the area under the curve (71.9%), maximum serum concentration (69.8%), absorption rate constant (37.3%), elimination rate constant (53.9%), clearance rate (76.5%) and volume of distribution (47.2%). However, there was a pronounced increase in the half-life of the drug (125.7%).


Keywords: chloroquine sulphate, Azadirachta indica (Meliaceae), pharmacokinetic interaction

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