Acta Pharm. 67 (2017) 325-339

 

full paper

Original research paper

 

Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation

R. RAJABALAYA, C. Y. MUN, J. CHELLIAN, S. CHAKRAVARTHI AND S. R. DAVID

sdsheba@gmail.com

1 PAPRSB Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan BE1410, Brunei Darussalam

2 School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia

3 School of Medicine, Perdana University, Jalan MAEPS Perdana, 43400 Serdang, Selangor, Malaysia

Accepted May 11, 2017

Published online June 1, 2017

The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential scanning calorimetry and Fourier transform infrared analyses were also performed. To determine patch effectiveness, in vitro release, permeation and animal studies were performed. The patches showed satisfactory percentage of release, up to 89.9 %, and their mechanical properties included thickness (0.100.15 mm), tensile strength (4.629.98 MPa) and modulus of elasticity (2029 MPa). There were no significant interactions between TT and other excipients. Animal studies indicated that the TT patch reduced the incidence of side effects; however, studies of longer duration are required to determine the effectiveness in treating OAB.

 

Keywords: tolterodine tartrate, transdermal, overactive bladder, matrix patches, permeation