Acta Pharm. 68 (2018) 441-455


full paper

Original research paper


Preparation and characterization of a novel aqueous dispersion for enteric coating of pantoprazole sodium pellets


1 College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China

2 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd., Hangzhou 310011, China


Accepted June 19, 2018

Published online July 16, 2018


The purpose of this work was to investigate a novel aqueous dispersion (Eudragit® L100-55) for enteric coating of drugs. Three different casting solutions, Eudragit® L100-55 aqueous dispersion, Eudragit® L100-55 organic solution, and Eudragit® L30D-55 aqueous dispersion, were used to prepare free films by the casting method. Drug-loaded pellets, prepared by the extrusion-spheronization method, were coated with one of these three coating solutions using the fluidized-bed spray coating technology. Properties of the free films were thoroughly investigated. Films formed by Eudragit® L100-55 aqueous dispersions showed similar properties to those formed by Eudragit® L100-55 organic solution regarding thermodynamic properties, moisture permeability, solubility and acid tolerance ability. Furthermore, the performance of the novel film was better than that formed by Eudragit® L30D-55 aqueous dispersion. Among the three enteric coating solutions, Eudragit® L100-55 aqueous dispersion will be a promising aqueous dispersion for enteric coating and can be used in the development of enteric-coated preparations.


Keywords: preparation of aqueous dispersion; Eudragit®L100-55; Eudragit®L30D-55; free films; enteric-coated pellets; acid tolerance ability