Acta Pharm. 52 (2002) 1-8

Synthesis od some new substituted acetylated benzoxazolinones with anti-nociceptive activity

UNSAL CALIS,^*  NESRIN GOKHAN and  HAKKI ERDOGAN

sucalis@tr.net

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey

In this study, ten new 3-methyl-6-(2-substituted aminoacetyl/propanoyl)-2-benzoxazolinone derivatives were prepared and their structures were determined by elemental analysis, IR and ¹H NMR data. The anti-nociceptive activities of these compounds were investigated using a modified Koster test. It was found that some of the synthessized compounds are capable of inducing anti-nociception i animals. 3-Methyl-6-(2-imidazolylacetyl)-2-benzoxazolinone (4b) has been found to be the most active among the synthesized compounds.

Keywords: 2-benzoxazolinone derivatives, acylation, anti-nociceptive activity