Acta Pharm. 53 (2003) 1-14

Isolation of 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl)quinolines by Vilsmeier Haack reaction on quinaldines: Construction of diazepino quinoline heterocycles and their antimicrobial and cytogenetic studies

RAJU NANDHA KUMAR, THANGARAJ SURESH  and   PALATHURAI SUBRAMINIAM MOHAN^*

ps_mohan_in @yahoo.com

Department of Chemistry, Bharathiar University, Coimbatore - 641 046, India

Application of Vilsmeier conditions to 4-hydroxy quinaldines gives 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl)quinolines as an intermediate. The latter is utilized to prepare diazepino quinolines on treatment with phenylhydrazine hydrochloride. All the synthesized compounds have been screened for their antibacterial and antifungal as well as cytogenetic activities.

Keywords: quinaldines, Vilsmeier Haack reaction, 4-chloro-3-formyl-2-(2-hydroxyethene-1-yl)quinolines, diazepinoquinolines, antimicrobial activity, cytogenetic activity