Acta Pharm. 54 (2004) 1-12

Synthesis and biological activity of substituted 2,4,6-s-triazines

VINOD KUMAR PANDEY,^1* SARAH TUSI,¹  ZEHRA TUSI,¹
MADHAWANAND JOSHI²  and SHASHIKALA BAJPAI²

a_zehra8@yahoo.com

¹Chemistry Department, University of Lucknow, Lucknow - 226007, India
²Division of Microbiology, Central Drug Research Institute, Lucknow - 226001, India

Reaction of 7-hydroxy-4-methyl coumarin with amido/imido alcohols in ethanol containing concentrated hydrochloric acid afforded 8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-coumarins (1a-f). Interaction of 1a-f with hydrazine hydrate in pyridine resulted in 1-amino-8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolines (2a-f). Treatment of 2 with formaldehyde in ethanol resulted in 1,3,5-tris-(8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)-2,4,6-hexahydro-s-triazines (3a-c). Antiviral activity of compounds 2a-d and 3a, 3b upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) was evaluated on vero cells in vitro. 3a-c were also screened for their antihypertensive activity.

Keywords: substituted 2,4,6-s-triazines, antiviral activity, antihypertensive activity