Acta Pharm. 56 (2006) 105-112

Properties of the copper(II)-histidine complex obtained after dialysis of human plasma with histidine

TONY VENELINOV¹, SONIA ARPADJAN^1*, IRINA KARADJOVA¹ and  JOHN BEATTIE²

SGaneva@chem.uni-sofia.bg

¹Sofia University, Faculty of Chemistry, Department of Analytical Chemistry, 1164 Sofia, Bulgaria
²Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen, AB21 9SB, UK

The copper(II)-histidine complex obtained following dialysis of human plasma with histidine was investigated using various types of extraction systems and ion exchange resins. According to the results obtained, the Cu(II)-histidine complex formed under the dialysis conditions has one positive charge. Preconcentration of copper from the dialysis solution was achieved by its extraction as a dithiocarbamate complex and by sorption on cation-exchange resin or onto chelate sorbent.

Keywords: copper-histidine, human plasma dialysis, extraction, ion-exchange