Acta Pharm. 65 (2015) 105-116
Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment
HANQING LIU, ZHIGANG TU, FAN FENG, HAIFENG SHI, KEPING CHEN and XIMING XU
1 School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China
2 Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China
Accepted February 9, 2015
A virosome is an innovative hybrid drug delivery system with advantages of both viral and non-viral vectors. Studies have shown that a virosome can carry various biologically active molecules, such as nucleic acids, peptides, proteins and small organic molecules. Targeted drug delivery using virosome-based systems can be achieved through surface modifications of virosomes. A number of virosome-based prophylactic and therapeutic products with high safety profiles are currently available in the market. Cancer treatment is a big battlefield for virosome-based drug delivery systems. This review provides an overview of the general concept, preparation procedures, working mechanisms, preclinical studies and clinical applications of virosomes in cancer treatment.
Keywords: virosome, drug delivery system, cancer treatment, cancer vaccine