Acta Pharm. 51 (2001) 107-115
Synthesis of a series of new fenoprofenamides 3a-j is described. Amide bonding was achieved by aminolysis of fenoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acids. The structures of synthesised compounds were fully characterised by IR, 1H and 13C NMR spectroscopies and elemental analysis. The synthesised compounds are potential prodrugs of a well known NSAID fenoprofen.
Keywords: fenoprofen, fenoprofenamide, synthesis, benzotriazole, prodrug