Acta Pharm. 51 (2001) 107-115

Acta Pharm. 51 (2001) 107-115

Original scientific paper

The novel fenoprofenamides - synthesis and spectroscopic characterisation

MARIJANA ZOVKO,¹ BRANKA ZORC,^1* MILENA JADRIJEVIC-MLADAR TAKAC¹
and DAVOR ZORC²

¹Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
²Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia

Received February 7, 2001 Accepted April 6, 2001

Synthesis of a series of new fenoprofenamides 3a-j is described. Amide bonding was achieved by aminolysis of fenoprofen benzotriazolide (2) with various amines: primary, secondary, hydroxylamine and amino acids. The structures of synthesised compounds were fully characterised by IR, ¹H and ¹³C NMR spectroscopies and elemental analysis. The synthesised compounds are potential prodrugs of a well known NSAID fenoprofen.

Keywords: fenoprofen, fenoprofenamide, synthesis, benzotriazole, prodrug

The novel fenoprofenamides - synthesis and spectroscopic characterisation

MARIJANA ZOVKO,1 BRANKA ZORC,1* MILENA JADRIJEVIC-MLADAR TAKAC1 and DAVOR ZORC2

1Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia2Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia

MARIJANA ZOVKO,¹ BRANKA ZORC,^1* MILENA JADRIJEVIC-MLADAR TAKAC¹
and DAVOR ZORC²

¹Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
²Faculty of Mechanical Engineering and Naval Architecture, University of Zagreb, Zagreb, Croatia