Acta Pharm. 50 (2000) 111-120

Synthesis of pyrano [2,3-d]pyrimidine and pyrano[3,2-e] [1,2,4]triazolo[2,3-c]pyrimidine derivatives with promising antibacterial activity

AHMED M. EL-AGRODY,^1* MAMDOUH H. EL-HAKIM,¹  MOHSEN S. ABD EL-LATIF,¹  
ASHRAF H. FAKERY, ¹  EL-SAYED M. EL-SAYED²  and   KAMAL A. EL-GHAREAB²

¹Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
²Department of Pharmacology and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

Several new naphtho[1',2':5,6]pyrano[2,3-d]pyrimidines (4, 5, 7, 8) were obtained by the reaction of enaminonitrile (3) and 2-ethoxymethylideneamino naphtho[2,1-b]-pyrane (6) with suitable reagents such as carboxylic acid derivatives, CS₂, C₆H₅NSC, ammonia, hydrazine, amines and H₂S, respectively. Polysubstituted pyrano[3,2-e]- [1,2,4]triazolo[2,3-c]pyrimidines (9, 13) were also prepared. Antimicrobial activities of the synthesised compounds were studied. Some of the compounds gave promising results.

Keywords: pyranopyrimidine derivatives, pyranotriazolopyrimidine derivatives, antibacterial agents