Acta Pharm. 50 (2000) 111-120

Original scientific paper  
 

Synthesis of pyrano [2,3-d]pyrimidine and pyrano[3,2-e] [1,2,4]triazolo[2,3-c]pyrimidine derivatives with promising antibacterial activity

AHMED M. EL-AGRODY,1* MAMDOUH H. EL-HAKIM,1  MOHSEN S. ABD EL-LATIF,1  
ASHRAF H. FAKERY, 1  EL-SAYED M. EL-SAYED2  and   KAMAL A. EL-GHAREAB2


1Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
2Department of Pharmacology and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt
Received November 2, 1999      Accepted March 24, 2000

Several new naphtho[1',2':5,6]pyrano[2,3-d]pyrimidines (4, 5, 7, 8) were obtained by the reaction of enaminonitrile (3) and 2-ethoxymethylideneamino naphtho[2,1-b]-pyrane (6) with suitable reagents such as carboxylic acid derivatives, CS2, C6H5NSC, ammonia, hydrazine, amines and H2S, respectively. Polysubstituted pyrano[3,2-e]- [1,2,4]triazolo[2,3-c]pyrimidines (9, 13) were also prepared. Antimicrobial activities of the synthesised compounds were studied. Some of the compounds gave promising results.


Keywords: pyranopyrimidine derivatives, pyranotriazolopyrimidine derivatives, antibacterial agents


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