Acta Pharm. 59 (2009) 111-117
Short communication
Formulation and evaluation of controlled
release antibiotic biodegradable implants for post operative site delivery
VIJAY
MATHUR, RAJESH MUDNAIK, LAXMIKANT BARDE, ARGHYA ROY, UMESH SHIVHARE and KISHORE
BHUSARI
mathurvb@gmail.com
Sharad
Pawar College of Pharmacy, Wanadongri, Hingna road, Nagpur-441110 (M.S.), India
Accepted January 11, 2010
Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000) glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by compression method showed more delayed release as compared to formulations prepared by molding method.
Keywords: biodegradable antibiotic
implants, glyceryl monostearate, controlled drug release, site delivery,
erosion enhancers