Acta Pharm. 51 (2001) 117-130

Acta Pharm. 51 (2001) 117-130

Original scientific paper

QSAR studies on antihypertensive activity of 4-(diarylmethyl)-N-substituted piperidines

VIJAY K. AGRAWAL,¹ RAJNEESH C. SRIVASTAVA¹ and PADMAKAR V. KHADIKAR^2*

¹Department of Chemistry, A.P.S. University, Rewa 486 003, India
²Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India

Received May 15, 2000 Accepted March 14, 2001

Antihypertensive activity of a series of 4-(diarylmethyl)-N- substituted-piperidines is modelled topologically using van der Waals volume (Vw), negentropy (N), and first-order valence connectivity index (¹X^v). The regression analysis of the data has shown that statistically significant QSAR models were obtained in multiparametric correlations upon addition of indicator parameters.

Keywords: antihypertensive activity, topological modelling, negentropy, QSAR, N-substituted piperidines, first-order valence connectivity index

QSAR studies on antihypertensive activity of 4-(diarylmethyl)-N-substituted piperidines

VIJAY K. AGRAWAL,1 RAJNEESH C. SRIVASTAVA1 and PADMAKAR V. KHADIKAR2*

1Department of Chemistry, A.P.S. University, Rewa 486 003, India2Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India

VIJAY K. AGRAWAL,¹ RAJNEESH C. SRIVASTAVA¹ and PADMAKAR V. KHADIKAR^2*

¹Department of Chemistry, A.P.S. University, Rewa 486 003, India
²Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India