Acta Pharm. 51 (2001) 117-130
Antihypertensive activity of a series of 4-(diarylmethyl)-N- substituted-piperidines is modelled topologically using van der Waals volume (Vw), negentropy (N), and first-order valence connectivity index (1Xv). The regression analysis of the data has shown that statistically significant QSAR models were obtained in multiparametric correlations upon addition of indicator parameters.
Keywords: antihypertensive activity, topological modelling, negentropy, QSAR, N-substituted piperidines, first-order valence connectivity index