Acta Pharm. 58 (2008) 15-27

full paper

Original research paper

Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

MOHAMED IBRAHIM HEGAB, NABIL MAHMOUD YOUSEF, HANY FATHY NOUR, MOHEY ELLITHEY and MAHMOUD SOLIMAN

apmihegab65@yahoo.com

¹Photochemistry Department, National Research Centre, Cairo, Egypt

²Pharmacology Department, National Research Centre, Cairo, Egypt

Accepted November 21, 2007

Some new hydrazono- 5a,b, thiosemicarbazono- 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding β-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.

Keywords: β-chlorocarbaldehyde, hydrazones, thiosemcarbazones, oxime ethers, anti-inflammatory activity, ulcerogenic activity