Acta Pharm. 57
(2007) 151-159
Original research paper
Development and evaluation of carvedilol transdermal patches
YUVERAJ
SINGH TANWAR*, CHETAN SINGH CHAUHAN and ANSHU SHARMA
yuveraj2000@yahoo.co.in
Bhupal Nobles’ College of Pharmacy, Udaipur-313001,
Rajasthan, India
Accepted February 15, 2007
Transdermal
patches of carvedilol with a HPMC-drug reservoir were
prepared by the solvent evaporation technique. In this investigation, the
membranes of Eudragit RL100 and Eudragit
RS100 were cast to achieve controlled release of the drug. The prepared patches
possessed satisfactory physicochemical characteristics. Thickness, mass and
drug content were uniform in prepared batches. Moisture vapour
transmission through the patches followed zero-order kinetics. In vitro
permeation studies were performed using a K-C diffusion cell across hairless
guinea pig skin and followed super case II transport mechanism. The effects of
non-ionic surfactants Tween 80 and Span 80 on drug
permeation were studied. The non-ionic surfactants in the patches increased the
permeation rate, Span 80 exhibiting better enhancement relative to Tween 80. The patches were seemingly free of potentially
hazardous skin irritation.
Keywords: carvedilol, transdermal
patches, in vitro permeation, permeation rate