Acta Pharm. 65 (2015) 15-27
Original research paper
Alginate microspheres
obtained by the spray drying technique as mucoadhesive carriers of ranitidine
MARTA
SZEKALSKA, ALEKSANDRA AMELIAN and KATARZYNA WINNICKA
1 Department of Pharmaceutical Technology, Medical
University of Bia³ystok, 15-222
Bia³ystok, Poland
2 Department of Clinical
Pharmacy, Medical University of Bia³ystok,
15-222 Bia³ystok, Poland
Accepted October 24, 2014
The present study is aimed at formulation of alginate (ALG) microspheres with ranitidine (RNT) by the spray drying method. Obtained microspheres were characterized for particle size, surface morphology, entrapment efficiency, drug loading, in vitro drug release and zeta potential. Mucoadhesive properties were examined by a texture analyser and three types of adhesive layers – gelatine discs, mucin gel and porcine stomach mucosa. Microspheres showed a smooth surface with narrow particle size distribution and RNT loading of up to 70.9 %. All formulations possessed mucoadhesive properties and exhibited prolonged drug release according to the first-order kinetics. DSC reports showed that there was no interaction between RNT and ALG. Designed microspheres can be considered potential carriers of ranitidine with prolonged residence time in the stomach.
Keywords: ranitidine, sodium alginate, microspheres, spray
drying technique, mucoadhesiveness