Acta Pharm. 67 (2017) 159-170
Original research paper
Development and evaluation of orally
disintegrating tablet containing
mosapride resin complex
TONG WU, GUANHUA WANG,
CAIHONG SHI, JINGHAN LI, NA ZHAO, ZIHAO DONG, WEISAN PAN and XIANGRONG ZHANG
1 School of Traditional Chinese Materia
Medica, Shenyang Pharmaceutical University, Shenyang
110016, P.R. China
2 School of Pharmacy,
Shenyang Pharmaceutical University, Shenyang 110016, Liaoning Province, P.R.
China
3 State Key Laboratory of Medicinal Resources,
Chemistry and Molecular Engineering, Guangxi Normal University, Gui Lin 541006, P.R. China
Accepted January 15, 2018
Published online February
6, 2018
The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, weight ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compression and were optimized using the response surface method. Optimized orally fast-disintegrating tablets disintegrated within 18 s. The pH dependence of mosapride release from the tablet decreased drug dissolution in simulated saliva, whereas it promptly released in the pH 1.0 solution. The data reported herein clearly demonstrate that tablets containing the mosapride- Amberlite® IRP 88 complex for oral disintegration could be particularly useful for patients with swallowing difficulties.
Keywords: mosapride citrate, Amberlite® IRP 88 resin, resin complex, orally
disintegrating tablet, physicochemical characterization, dissolution