Acta Pharm. 58 (2008) 175-186

full paper

Original research paper

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

Hanaa M. Hosni and Mohamed M. AbdullA

hanaanrc@yahoo.com

Pesticide Chemistry Department, National Research Centre, Doki, Cairo, Egypt

Research Units, Hi-Care Pharmaceutical Co., Cairo, Egypt

Accepted March 27, 2008

In continuation of our search for new substituted pyridine based anti-inflammatories, reaction of 1-(2-thienyl or furanyl)-3-(2-hydroxyphenyl)-2-propen-1-ones (1) with malononitrile in alcoholic KOH solution afforded a mixture of 4-alkoxy-2-(2-thienyl or furanyl)-5H-[1]benzopyrano[3,4-c]pyridine-5-ones (2) and 2-alkoxy-4-amino-6-(2-thienyl or furanyl)-3,5-pyridinedicarbonitriles (3). Some of the synthesized compounds were evaluated for their anti-inflammatory and analgesic activities compared to diclofenac potassium as positive control. Detailed synthesis, spectroscopic and toxicity data are reported.

Keywords: pyridinedicarbonitrile, benzopyranopyridine, anti-inflammatrory, analgesic agents