Acta Pharm. 60 (2010) 185-195

 

full paper

Original research paper

 

Impact of superdisintegrants on efavirenz release from tablet formulations

YELCHURI VIJAYA RAJESH, JAGDISH BALASUBRAMANIAM, KODURI BINDU, RAMACHANDRAN SRIDEVI, MAROJU SWETHA, VINAY UMESH RAO
rajeshyelchuri@rediffmail.com

1 International Specialty Products India Pvt Limited, 6-3-1090/A, Bhupal Towers, Rajbhavan Road, Somajiguda, Hyderabad-500082, India

2 Daewoong Pharmaceutical Co., Ltd., Indian Branch Office, C-54/A, Techni Towers, IVth floor, A.P.I.E., Balanagar, Hyderabad-500037, India

3 RA Chem Pharma Limited, Road No 18, IDA, Nacharam, Hyderabad-500076, India

Accepted April 12, 2010

 

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrant extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the propensity to discriminate between the formulations.

The t50 and t80 values were indicative of the fact that drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.

 

Keywords: efavirenz, superdisintegrants, granulation