Acta Pharm. 61 (2011) 187-201

 

full paper

Original research paper

 

Synthesis, antibacterial and potential anti-HIV activity of some novel imidazole analogs

SWASTIKA GANGULY, VATSAL VIJAY VITHLANI, ANUP KUMAR KESHARWANI, RITU KUHU, LAKSHMANAN BASKAR, PAPIYA MITRAMAZUMDER, ASHOK SHARON and ABHIMANYU DEV

swastikaganguly@bitmesra.ac.in

1 Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

 

2 Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

Accepted May 6, 2011

 

A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylamino-propan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.

 

Keywords: imidazole, reverse transcriptase, non-nucleoside reverse transcriptase, anti-HIV, antibacterial