Acta Pharm. 67 (2017) 187-202
Original research paper
Influence of
concentration and type of microcrystalline cellulose on the physical properties
of tablets containing Cornelian cherry fruits
ALEŠ FRANC, SLAVOMIR KURHAJEC, SYLVIE PAVLOKOVÁ, DANA
SABADKOVÁ and JAN MUSELÍK
1 Department of Pharmaceutics, University of Veterinary and Pharmaceutical
Sciences, 612 42 Brno, Czech Republic
2 Department of Pharmacognosy and Botany,
University of Veterinary Medicine and Pharmacy, 041 81 Košice,
Slovakia
Accepted February 28, 2017
Published online March 31,
2017
The aim of this study was to find
the optimal tablet composition with maximum content of dried fruits (Cornus mas L.). The
effect of three different concentrations (12.5, 25 and 50 %) of two types of
microcrystalline cellulose (Avicel® PH 101
and Avicel® PH 200) and three different
compression pressures (20, 60 and 100 MPa) on the
physical properties of tablet blends and tablets was
studied. Tablets containing 50 % Avicel®
PH 101 compressed under 100 MPa were found to have
the best physical properties. This combination of composition and compression
pressure resulted in stable tablets even after storage under accelerated
stability conditions (6 months, 40 °C and 75 % RH).
Keywords: Cornus mas, microcrystalline cellulose, direct
compression, accelerated stability, principal component analysis