Acta Pharm. 52 (2002) 189-196

Binary and ternary complexes of sulphathiazole

EMAN M. SHOUKRY

shoukrym@hotmail.com

Department of Chemistry, Faculty of Science (for Girls), Al-Azhar University, Nasr City, Cairo, Egypt

The complex formation equilibria involved in the binary and ternary systems M(II)-HS and M(II)-NTA-HS were investigated by potentiometric titrations at 25 ^oC and ionic strength of 0.1 mol L^-1 NaNO₃ (M = Cu^II, Ni^II, Co^II, Zn^II, Cd^II, Mn^II, Mg^II, Sr^II, Ba^II, and Hg^II, HS = sulphathiazole, NTA = nitrilotriacetic acid). The formation of the ternary complex was discussed in terms of the binary species. The distribution of the complexes was evaluated. The mode of chelation was ascertained by conductivity measurements.

Keywords: sulphatiazole, complex, potentiometric titration