Acta Pharm. 62 (2012) 191-200
Original research paper
Simultaneous
determination of methocarbamol and ibuprofen or diclofenac potassium using mean
centering of the ratio spectra method
NOURUDDIN WAGEIH ALI, MAHA AHAMD HEGAZY, MOHAMED
ABDELKAWY and EGLAL ABDELAHAMID ABDELALEEM
1
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef
University, Beni-Suef, Egypt
2
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo
University, Cairo, Egypt
Accepted April 16, 2012
Accurate and sensitive methods were developed for simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium in their binary mixtures, and in presence of a methocarbamol related substance (guaifenesin) using mean centering of the ratio spectra method. The results obtained were statistically compared with the reported HPLC methods; no significant difference between the proposed methods and the reported methods was found regarding either accuracy or precision.
Keywords: methocarbamol, diclofenac potassium, ibuprofen; mean centering of ratio
spectra, guaifenesin