Acta Pharm. 52 (2002) 197-206

Short communication  
 

Synthesis and antibacterial screening of novel sulphonamide Mannich bases

SHEELA JOSHI,* NAVITA KHOSLA,  DEEPAK KHARE 
and   PRAPTI TIWARI 

deepak_kh75@yahoo.co.in

1School of Chemical Sciences, Devi Ahilya University, Indore-452017, India
Received July 6, 2001      Accepted September 6, 2002

A series of Mannich bases with chloro- and nitro-substituted benzamide have been synthesized by the Mannich reaction of substituted chlorobenzamide with various sulphonamides and secondary amines. Elemental analysis and spectral data (UV, IR and 1H NMR) were used for their characterization. Screening against various pathogenic Gram positive and Gram negative bacteria pointed to significant antimicrobial behaviour of the newly synthesized Mannich bases with the nitro substituted phenylene system and sulphonamide moiety. All the compounds were found to be of low toxicity.


Keywords: sulphonamides, Mannich bases, antibacterial activity, toxicity