Acta Pharm. 49 (1999) 1-10

Synthesis and effect of some new [1,2,4]triazolo [4,3-a]quinazolin-5(4H)-ones and related compounds on Ehrlich Ascites Carcinoma cells

MOUSTAFA M. GHORAB,^*1  SAMI G. ABDEL-HAMIDE,²  MOHAMED S. A. EL-GABY,³ 
and   SAMI M. EL-SAYED⁴

¹Department of Drug Radiation Research,  National Center for Radiation Reasearch and Technology,  P.O. Box 29,  Nasr City,  Cairo
²Pharmaceutical Chemistry Department,  Faculty of Pharmacy,  Al-Azhar University,  Nasr City,  Cairo,  Egypt 
³Department of Chemistry,   Faculty of Science,   Al-Azhar University at Assiut,  Assiut 71511,  Egypt 
⁴Biology Department,  National Center for Radiation Research and Technology,  Cairo,  Egypt

Synthesis of several new 7-iodo-4-phenyl-1-substituted-[1,2,4]triazolo[4,3-a] quinazolin-5(4H)-ones (IX, XIII, XV, XVI, XXIII, XXVI) and related heterocycle compounds have been reported. The structures of newly prepared compounds were confirmed by elemental analysis, chemical reactions and spectral data. Compounds VIII , XIX, XX and XXVI acted as potent cytotoxic agents.

Keywords: triazolo[4,3-a]quinazolin derivatives, cytotoxic effects