Acta Pharm. 54 (2004) 205-214

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Original research paper 
 

Preparation and evaluation of floating risedronate sodium Gelucire® 39/01 matrices

BHASKAR CHAUHAN, SHYAM SHIMPI, KAKASAHEB R. MAHADIK and ANANT PARADKAR*

anant_paradkar@yahoo.com

Department of Pharmaceutics, Bharati Vidyapeeth Deemed University,Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India
Received March 18, 2004      Accepted August 5, 2004

Incorporation of bisphosphonates in the lipid reduces gastric irritation. Only gastric retention with sustained release allows the drug to reach the duodenum and jejunum and improves the availability of bisphosphonates. Risedronate sodium and Gelucire® 39/01 floating matrices were prepared using melt solidification. The sustained release floating matrices were evaluated for in vitro and in vivo floating ability and in vitro drug release. Ageing of the matrices was studied by differential scanning calorimetry, hot stage polarizing microscopy, scanning electron microscopy and in vitro drug release. Ageing causes changes in the crystal structure of the Gelucire®, which is responsible for increase in drug release.


Keywords: risedronate sodium, Gelucire® 39/01, hot stage polarizing microscopy, ageing, scanning electron microscopy