Acta Pharm. 53 (2003) 213-221[ Full paper in PDF ]
A variety of novel bisthiazolopyridine derivatives 4a-e were synthesized via the reaction of bisthiazolinone 3 with different aryl cinnamonitrile derivatives (1:2 molar ratio), whereas the reaction of bis-compounds 7a-e with malononitrile in ethanol solution containing a few drops of piperidine afforded the novel bisthiazolopyridines 8a-e. The structures of the synthesized compounds were established by elemental analyses and spectral data. Some of the newly synthesized compounds show moderate to high antimicrobial activity.
Keywords: bisthiazolopyridines, synthesis, antimicrobial activity