Acta Pharm. 53 (2003) 213-221

Studies on thiazolopyridines - A novel synthesis of bisthiazolopyridines as promising antimicrobial agents

MOHAMED E. AZAB, ¹  GAMEEL A. M. EL-HAG ALI^2*and  ASHRAF H. F. ABD EL-WAHAB²

elahag1970@hotmail.com

¹Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt
²Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, P.O. Box 11884, Cairo, Egypt

A variety of novel bisthiazolopyridine derivatives 4a-e were synthesized via the reaction of bisthiazolinone 3 with different aryl cinnamonitrile derivatives (1:2 molar ratio), whereas the reaction of bis-compounds 7a-e with malononitrile in ethanol solution containing a few drops of piperidine afforded the novel bisthiazolopyridines 8a-e. The structures of the synthesized compounds were established by elemental analyses and spectral data. Some of the newly synthesized compounds show moderate to high antimicrobial activity.

Keywords: bisthiazolopyridines, synthesis, antimicrobial activity