Acta Pharm. 53 (2003) 223-229[ Full paper in PDF ]
Dihydropyrimidines 4a-r have been synthesized by base catalysed condensation of beta-aroylpropanoic acid, guanidine nitrate and aromatic aldehyde. Structures of new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with standard drug diclofenac sodium.
Keywords: dihydropyrimidine, aryl alkanoic acids, anti- inflammatory activity