Acta Pharm. 58 (2008) 231-236
Short communication
N-Phthaloyl-glycine-hydroxamic acid as serum
iron chelator in rats
JULIJA
MATIJEVIĆ-SOSA, ITA SAMARŽIJA, LORENA HONOVIĆ and BLAŽENKA JURIŠIĆ
jmatijevic@pharma.hr
Faculty of Pharmacy and Biochemistry, University
of Zagreb, Croatia
Clinical Laboratory, General Hospital Pula,
Croatia
Agency for Medicinal Products and Medicinal
Devices of Republic of Croatia
Accepted May 7, 2008
The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid
(Phth-Gly-HA) as a new iron chelator in
vivo to be used in iron overload diseases. After intraperitoneal application
of Phth-Gly-HA to male rats (1 mg kg-1 body mass) once a day for seven
days, iron serum level decreased by 21%, whereas the iron value dropped by 32%
in female rats (1.5 mg kg-1 body mass). The results indicate that the tested substance has the
ability to bind serum iron by complexation. Besides transferrin iron release,
mobilization of ferritin iron is also possible.
Keywords: N-phthaloyl-glycine-hydroxamic
acid, iron chelators, iron overload