Acta Pharm. 63 (2013) 231-239

 

full paper

Short communication

 

Synthesis and potential antimicrobial studies on some Mannich bases carrying imidazole moiety

PRIYA VINEETHA FRANK, MAHESHA MANJUNATHA POOJARY, NARAL DAMODARA and CHANDRASHEKHAR CHIKKANNA

priyafrank@gmail.com

1 Department of Chemistry, Canara Engineering College, Benjanapadavu, Mangalore-574219, Karnataka, India

2 PG Department of Medicinal Chemistry, SDM College, Ujire-574240, Karnataka, India

Accepted January 17, 2013

 

Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione (3) was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

 

Keywords: imidazole derivatives, Mannich bases, oxadiazole, antibacterial activity, antifungal activity