Acta Pharm. 55 (2005) 237-249

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Original research paper  
 

Synthesis and antimicrobial screening of some fused heterocyclic pyrroles

MOUSAD S. MOHAMED,1 AYMN E. RASHAD,*2 MAGDY E. A. ZAKI 2 and SAMAR S. FATAHALA1

aymnelzeny@yahoo.com

1 Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
2 Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt
Received November 10, 2004      Accepted August 2, 2005

Pyrrole derivatives 1a,b were used as precursors for the preparation of pyrrolo[2,3-d]pyrimidine derivatives 2a,b-7a,b. Also, the formation and structure of different pyrrolotriazolopyrimidine derivatives 8a,b-11a,b were discussed. Some of the prepared products showed potent antimicrobial activity.


Keywords: pyrrole, pyrrolo[2,3-d]pyrimidine, pyrrolotriazolo- pyrimidine, antimicrobial activity