Acta Pharm. 50 (2000) 239-248

Synthesis and potential antibacterial activity of some
1,3-benzoxazin-4-one derivatives

NABAWEYA SHARAF EL-DIN

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Tanta, Tanta, Egypt

A series of 2,3-disubstituted-1,3-benzoxazine-4-one derivatives has been synthesised via the reaction of salicylic acid with various primary amines followed by the cyclisation of the isolated amides with different aldehydes in acidic medium. In addition, 2-substituted-1,3-benzoxazine-4-one derivatives were prepared by condensation of salicylamide with various aldehydes. Spectroscopic data and elemental analyses substantiated the structure of the prepared compounds. Most of the synthesised compounds were found promising as antibacterial agents.

Keywords: 2,3-disupstituted benzoxazine derivatives, 2-supstituted benzoxazine derivatives, antibacterial activity, salicylic acid, salicylamides