Acta Pharm. 48 (1998) 249-258

Original scientific paper  
 

Effect of novel biologically active oxadiazino-, oxadiazolo-, and oxathiadiazolo- quinazolinones on non-irradiated and radioresistant Staphylococcus aureus

SAMI G. ABDEL-HAMIDE,1   MOUSTAFA M. GHORAB,*2 and  HALA N. EL-HIFNAWI2

1Pharmaceutical Chemistry Department,  Faculty of Pharmacy,  Al-Azhar University,  Nasr City,  Cairo,  Egypt 
2Department of Drug Radiation Research,  National Center for Radiation Reasearch and Technology,
  P.O. Box 29,  Nasr City,  Cairo,  Egypt 
Received April 21, 1998      Accepted October 20, 1998

Searching for new antibacterial agents, some new quinazolinones containing oxadiazino, oxadiazolo and oxathiadiazolo moieties have been synthesized. The former structure of the new products was deduced from elemental analysis and spectral data. Compounds I, V, XVI, XVII, XIX and XX showed a remarkable activity against the growth of non-irradiated Staphylococcus aureus, while the compound XVI exhibited higher activity against radioresistant Staphylococcus aureus.

Keywords: quinazolinones, synthesis, antibacterial activity