Acta Pharm. 53 (2003) 25-31

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Original research paper  
 

Hydrogels based on the chemically crosslinked polyacrylic acid: Biopharmaceutical characterization

MILEN DIMITROV,1 NIKOLAI LAMBOV,1*  STOICHO SHENKOV,2 
VENETA DOSSEVA2and   VLADIMIR Y. BARANOVSKI2 

nlambov@pharmfac.acad.bg

1Department Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Sofia, Bulgaria
2Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
Received February 28, 2002      Accepted February 11, 2003

This study is an attempt of biopharmaceutical characterization of hydrogels based on crosslinked polyacrylic acid (PAA). Macrodiisocyanates (MDIC) or oligomethanediisocyanate (DO) were used as crosslinking agents. The drug release rate from such hydrogels is determined by the density of the net and is lowered by a decrease in the PAA : MDIC mass ratio. The increase of the drug concentration in the matrix improved the release process. The drug release from the hydrogels was found pH dependent.


Keywords: hydrogels, polyacrylic acid network, crosslinking, macrodiisocyanates, drug release