Acta Pharm. 51 (2001) 251-261

Synthesis and potential antimicrobial activity of some new compounds containing the pyrazol-3-one moiety

MOHAMED ALI AL-HAIZA,  SAIED ABDULLAH EL-ASSIERY  and   GALAL HOSNI SAYED^*

King Khaled University, College of Science, Department of Chemistry, Abha, Saudi Arabia

Pyrazolone derivative (3) was prepared by the nucleophilic addition of 2,5-diphenyl-2,4-dihydro-3H-pyrazol-3-one (1) to chalcone (2). Reaction of 3 with hydrazine hydrate, phenylhydrazine, hydroxylamine hydrochloride, p-chlorobenzaldehyde, acetyl chloride and phosphorus pentasulfide afforded the corresponding hydrazone, phenylhydrazone, oxime, arylidene, O-acetyl and dithio derivatives. Pyrazolone 1 was condensed also with cyclohexanone and aromatic aldehydes; the behaviour of the obtained arylidene derivatives towards hydrazines, cyclohexanone, malononitrile and urea was also investigated. Some of the new compounds showed antimicrobial and antifungal activities.

Keywords: pyrazol, synthesis, antimicrobial activity