Acta Pharm. 54 (2004) 251-260

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Short communication  
 

Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)- delta2-1,2,4-triazoline-5-thiones

MONIKA WUJEC,1 MONIKA PITUCHA,1 MARIA DOBOSZ, 1* URSZULA KOSIKOWSKA 2
and ANNA MALM2

wujec@panaceum.am.lublin.pl

1Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Lublin, Poland
2Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University, Lublin, Poland
Received March 12, 2004      Accepted September 3, 2004

In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.


Keywords: 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1,2,4-triazoline-5-thiones, synthesis, spectral analysis, antimycotic activity