Acta Pharm. 63 (2013) 253-264

full paper

Short communication

Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

SUBRAMANIYAN ARULMURUGAN and HELEN P. KAVITHA

helenkavithap@yahoo.co.in

Research Department of Chemistry, SRM University, Ramapuram, Chennai, Tamil Nadu, India

Accepted January 24, 2013

The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles 2, 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazole 4, 9, 15 and 21, tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, ¹H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell line such as, MCF-7 (breast cancer) and HT-29 (colon cancer) by MTT assay method. Among the tested compounds, compounds 4,4’-sulfonylbis(N-(2-(1H-benzo[d]imidazol-2-yl)ethyl)aniline (9), N-bis(2-(benzo[d]oxazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (13), N-bis(2-(1H-benzo[d]imidazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (15) and N-tris(2-1H-benzo[d]imidazol-2-yl)ethyl)-1,3,5-triazine-2,4,6-triamine (21) show potent cytotoxicity.

Keywords: benzimidazoles, imidazoles, benzoxazoles, tetrazoles, synthesis, cytotoxicity, MTT assay