Acta Pharm. 65 (2015) 253-270

full paper

Original research paper

Conventional versus ultrasound and microwave synthesis: Some new environmentally friendly functionalized picolinium-based ionic liquids with potential antibacterial activity

MOUSLIM MESSALI

mouslim@mail.be

Chemistry Department, Faculty of Science, Taibah University, 30002, Al-Madina Al-Munawara, Saudi Arabia

Accepted June 19, 2015

A green chemistry approach has been adopted for the synthesis of thirty-four new picolinium-based ionic liquids by using microwave (MW) and ultrasound (US) irradiation as well as conventional thermal heating. Their structures were confirmed by FT-IR, ¹H NMR, ¹³C NMR, ¹¹B NMR, ¹⁹F NMR, ³¹P NMR, mass spectra and elemental analyses. The antimicrobial profile of these novel ionic liquids was evaluated and the minimum inhibitory concentration (MIC) showed their moderate to low antimicrobial activity against eight types of human pathogens.

Keywords: picolinium-based ionic liquids, ultrasound irradiation, microwave irradiation, green procedure, antimicrobial activity