Acta Pharm. 59 (2009) 259-271
Original research paper
Metalloantibiotics: Synthesis, characterization
and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori
ANWAR R. SHAIKH, RAJANI GIRIDHAR, FRANCIS MEGRAUD and MANGE RAM YADAV
1 Pharmacy
Department, Faculty of Technology and Engineering, The M. S. University of
Baroda, Vadodara-390 001, India
2 Laboratoire de Bacteriologie,
Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie
Raba-Léon, 33076 Bordeaux cedex, France
Accepted July 9, 2009
Novel organometallic compounds have
been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin,
ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with
bismuth. The complexes were characterized by UV, IR, atomic absorption
spectroscopy, elemental analysis, differential scanning calorimetry,
thermogravimetric analysis and mass spectrometry. Their antibacterial potential
against Helicobacter pylori and other microorganisms was investigated.
These compounds were found to possess strong activity against Helicobacter
pylori at a minimum inhibitory concentration of 0.5 mg L-l. They also exhibited moderate activity against
Escherichia coli, Staphylococcus aureus, Bacillus
pumilus and Staphylococcus
epidermidis. These
bismuth-fluoroquinolone complexes have the potential to be developed as drugs
against H. pylori related ailments.
Keywords: fluoroquinolone, bismuth, complex, antimicrobial activity, Helicobacter pylory