Acta Pharm. 60 (2010) 267-280

full paper

Original research paper

Design and evaluation of taste masked dextromethorphan hydrobromide oral disintegrating tablets

MADHUSUDHAN MALLADI, RAJU JUKANTI, RASHMI NAIR, SANJAY WAGH, HARI SHANKER PADAKANTI and ASHOK MATETI

jukantiraj@gmail.com

¹CPS Formulations, DR. Reddy’s Laboratories Limited, Bachupally, Hyderabad-500090, India

²Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Hanamkonda, Warangal-506001, India

Accepted July 30, 2010

The present study is aimed to develop dextromethorphan hydrobromide (DXM) oral disintegrating tablets (ODT) with acceptable palatability to help patients of all age group. The bitter taste of the drug was masked by binding the drug to ion exchange resin. The effect of particle size of resin on drug loading was studied. In vitro and in vivo disintegration time and in vitro drug release studies were performed. Drug loading increased significantly with a decrease in the particle size of the resin. DSC and XRPD studies reveal that the molecular state of the drug changed from crystalline to amorphous form. The dissolution efficiency calulated for optimized ODT and conventional directly compressed tablet were almost comparable, indicating free dissociation of the drug from the resinate. The bitter taste of DXM can be masked by binding with ion exchange resin and the resinate can be successfully formulated into oral disintegrating tablets.

Keywords: dextromethorphan hydrobromide, ion exchange resin, taste masking, superdisintegrants