Acta Pharm. 49 (1999) 267-273
The parametric representation of dissolution data of carbamazepine from hydrophilic matrices is discussed using the Rosin-Rammler-Sperling-Bennett-Weibull (RRSBW) distribution. In the investigations different hydroxypropyl methylcelluloses (MethocelK 100LV, K 4M, K 15M and K 100M) were examined to formulate slow release carbamazepine tablet. The effect of the amount of low-substituted hydroxypropyl cellulose (L-HPC) on the dissolution was also examined. The RRSBW parameters of dissolution-rate curves were compared with each other and with the parameters of the commercial carbamazepine tablet (Tegretol SR 400) dissolution curve. Our results show that hydrophyllic matrix tablets containing hydroxypropyl methyl and low-substituted hydroxypropyl celluloses have the same dissolution properties as the Tegretol SR 400 tablets. The RRSBW distribution has been found a reliable mathematical method for comparing dissolution curves of investigated dosage forms and for examining whether in vitro they are equivalent or not.
Keywords: carbamazepine, tablet, dissolution, HPMC, L-HPC, Rosin-Rammler-Sperling-Bennett-Weibull distribution