Acta Pharm. 52 (2002) 269-280

Activated nitriles in heterocyclic synthesis: Synthesis of new [1]benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidine and [1]benzopyrano[3',4':5,6]pyrano[3,2-e][1]triazolo[1,5-c]pyrimidine derivatives with promising antibacterial activity

ASHRAF H. F. ABD EL-WAHAB¹

ash_abdelwahab@hotmail.com

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt

2-Amino-5-oxo-pyrano[3,2-c]benzopyrane-3-carbonitrile derivative (3) was used as precursor for the synthesis of novel benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidines (4, 6, 7 and 10), benzopyrano[3',4':5,6]pyrano[3,2-e][1,2,4]triazolo[1,5-c]pyrimidines (9, 11 and 15), and two 2-amino derivatives of pyrano[3,2-c][1]benzopyrans (5, 8). The antibacterial screening for new products was performed.

Keywords: pyrano[3,2-c]benzopyranes, pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines, antibacterial activity