Acta Pharm. 50 (2000) 273-280
N-[hydroxyethyl]-4-methyl-7-hydroxy carbostyryl (1) was prepared by condensing 4-methyl- 7-hydroxy coumarin with 2-aminoethanol in pyridine. Reaction of 1 with benzoic acid in conc. H2SO4 afforded N-[ethyl-meta-carboxyphenyl]-4-methyl-7-hydroxy carbostyryl (2) which upon treatment with benzoin in polyphosphoric acid (PPA) yielded 7-[N'-ethyl-2'-oxo-4'-methyl-7'- hydroxyquinolinyl]-3,4-diphenyl isocoumarin (3). Interaction of 3 with aromatic primary amines in pyridine resulted in 7-[2'-oxo-4'-methyl-7'-hydroxy-N-ethylquinolinyl]-1-oxo-2-aryl -3,4-diphenyl isoquinolines (4). Antiviral activity of the latter compounds was evaluated upon Japanese encephalitis virus (JEV) and Herpes simplex virus (HSV) activity on viro cells in vitro and in vivo.
Keywords: antibacterial agents, antimalarials, quinolinyl isoquinolines, isocoumarin, cytotoxicity, inhibition, antiviral assay