Acta Pharm. 49 (1999) 275-280

Original scientific paper  
 

Transport kinetics of Zn-ciprofloxacin complex across the model lipid membrane

STANISLAV PRIMOZIC,1   FRANC KOZJEK,1*  VOJKO KMETEC,1  and   MARJAN VEBER2

1Faculty of Pharmacy, University of Ljubljana, Ljubljana, 
2Faculty of Chemistry and Chemical Engineering, University of Ljubljana, Ljubljana, Slovenia  
Received June 28, 1999      Accepted August 31, 1999

Diffusion rate constants of ciprofloxacin and zinc-ciprofloxacin complex were assessed in two-compartment absorption apparatus with cellulose-based lipid membrane. The concentration of transported ciprofloxacin was determined by UV-Vis spectrometry and that of zinc by AAS. The ciprofloxacin and zinc ions passed the lipid membrane separately with significantly different diffusion rates and with no interaction effects. Diffusion rate constants obtained for ciprofloxacin (1.62-0.05 mm h-1) and zinc (0.41-0.20 mm h-1) in the transport of zinc-ciprofloxacin complex were comparable with corresponding values of the two species when transported independently.


Keywords: zinc-ciprofloxacin complex, transport kinetics, diffusion rate constants