Acta Pharm. 54 (2004) 277-285

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Original research paper  
 

2D NMR spectroscopic analyses of archangelicin from the seeds of Angelica archangelica

MELANIE MULLER,1 MAUREEN BYRES1, MARCEL JASPARS2, YASHODHARAN KUMARASAMY,1 MOIRA MIDDLETON,1 LUTFUN NAHAR,3 MOHAMMAD SHOEB1 and SATYAJIT D. SARKER1

s.sarker@rgu.ac.uk

1Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland, UK
2Marine Natural Products Laboratory, Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, Scotland, UK
3School of Life Sciences, The Robert Gordon University, St Andrew Street, Aberdeen AB25 1HG, Scotland, UK
Received April 28, 2004      Accepted September 17, 2004

A total of six coumarins, bergapten (1), xanthotoxin (2), imperatorin (3), isoimperatorin (4), phellopterin (5) and archangelicin (6), have been isolated from an n-hexane extract of the seeds of Angelica archangelica. The results of comprehensive 2D NMR analyses of archangelicin are discussed.


Keywords: Angelica archangelica (Apiaceae), furanocoumarins, archangelicin, 2D NMR