Acta Pharm. 50 (2000) 281-290
H1-antagonistic activity for a series of 2-(4-and 3- substituted phenyl(-3-[3-(N,N-dimethyl- amino)propyl]-1,3-thiazolidine-4-ones was modelled using molecular redundancy (MRI) and first-order valence connectivity index (1xv) indices. The results have shown that antagonist potency (pA2) could be modelled in multiparametric correlation on introduction of dummy parameters Ip1 and Ip2 (indicator parameters). Weighted Wiener and Szeged indices (Ww and Szw) were used as substituent parameters.
Keywords: thiazolidine-4-ones, QSAR, molecular redundancy index, valence connectivity index, Szeged index, Wiener index, antihistaminic activity, H1-histamine antagonists