Acta Pharm. 50 (2000) 281-290

Acta Pharm. 50 (2000) 281-290

Original scientific paper

QSAR studies on antihistaminic activity of some thiazolidine-4-ones

VIJAY K. AGRAWAL,¹ SHAILJA SACHAN¹ and PADMAKAR V. KHADIKAR²

¹Department of Chemistry, A.P.S. University, Rewa 486 003, India
²Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India

Received January 11, 2000 Accepted September 25, 2000

H₁-antagonistic activity for a series of 2-(4-and 3- substituted phenyl(-3-[3-(N,N-dimethyl- amino)propyl]-1,3-thiazolidine-4-ones was modelled using molecular redundancy (MRI) and first-order valence connectivity index (¹x^v) indices. The results have shown that antagonist potency (pA₂) could be modelled in multiparametric correlation on introduction of dummy parameters Ip₁ and Ip₂ (indicator parameters). Weighted Wiener and Szeged indices (W_w and S_zw) were used as substituent parameters.

Keywords: thiazolidine-4-ones, QSAR, molecular redundancy index, valence connectivity index, Szeged index, Wiener index, antihistaminic activity, H₁-histamine antagonists

QSAR studies on antihistaminic activity of some thiazolidine-4-ones

VIJAY K. AGRAWAL,1 SHAILJA SACHAN1 and PADMAKAR V. KHADIKAR2

1Department of Chemistry, A.P.S. University, Rewa 486 003, India 2Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India

VIJAY K. AGRAWAL,¹ SHAILJA SACHAN¹ and PADMAKAR V. KHADIKAR²

¹Department of Chemistry, A.P.S. University, Rewa 486 003, India
²Research Division, Laxmi Pest and Fumigation Pvt. Ltd. 3, Khatipura, Indore 452 007, India