Acta Pharm. 52 (2002) 281-287

Short communication  
 

Synthesis and anti-inflammatory activity of 1,4-dihydropyridines

SUSHILKUMAR BAHEKAR and DEVANAND SHINDE*

sushil@chemist.com

1Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, MS India
Received May 4, 2002      Accepted November 4, 2002

1,4-Dihydropyridines 1-21 have been synthesized by treating different aromatic aldehydes with beta-aroylpropanoic acid and ammonia. The structures of the new compounds were established on the basis of 1H NMR and IR spectral data. Anti-inflammatory activity in vivo was evaluated and compared with the standard drug, diclofenac sodium. Some compounds showed moderate activity.


Keywords: 1,4-dihydropyridines, aryl alkanoic acids, anti-inflammatory activity