Acta Pharm. 48 (1998) 281-288

The importance of levels of serum apoproteins A-I and B and their ratio as markers in predicting the extent of coronary artery disease

VASKA ARSOVA^* and   MARICA NOSPAL 

Institute of Clinical Biochemistry,   Clinic of Cardiology,   Clinical Centre,   Skopje,   Macedonia 

This study was performed to determine relations between concentrations of apoproteins A-I, B, serum lipids, and apo A-I/apo B ratio and extent of coronary obstruction in patients with coronary artery disease established angiographically.
The results showed that apo A-I and apo A-I/apo B ratio significantly differ not only among the groups of coronary artery disease patients and the group of disease-free subjects, but also between subgroups of patients divided on the basis of the extent of coronary obstruction. In patients with multi-vessel disease compared to the group of disease-free subjects the difference was even higher. No significant difference was found for apo B values between the groups of patients with double- or multi-vessel disease, but compared to the 1^st group – disease-free subjects, significant difference was observed. Decreased apo A-I and apo A-I/apo B ratio were accompanied by lower high-density lipoprotein.
Apo A-I, apo B and apo A-I/apo B ratio could be used as markers for establishing diagnosis in coronary artery disease in male patients, while only the apo A-I/apo B ratio together with the risk factors mentioned above have positive correlation with the extent of coronary artery stenosis.

Keywords: lipoprotein A-I, lipoprotein B, HDL-cholestreol, LDL-cholesterol, VLDL-cholesterol